Razimycin 200mg Suspension

Indications :-

Streptococcus pyogenes (Group A beta-haemolytic streptococcus):
Upper and lower respiratory tract, skin and soft tissue infections of mild to moderate severity.When oral medication is preferred for treatment of streptococcal pharyngitis and in long term prophylaxis of rheumatic fever, erythromycin is an alternate drug of choice.

When oral medication is given, the importance of strict adherence by the patient to the prescribed dosage regimen must be stressed. A therapeutic dose should be administered for at least 10 days.

Prevention of Initial Attacks of Rheumatic Fever:
Penicillin is considered to be the drug of choice in the prevention of initial attacks of rheumatic fever (treatment of Group A beta-haemolytic streptococcal infections of the upper respiratory tract e.g. tonsillitis or pharyngitis). Erythromycin is indicated for the treatment of penicillin-allergic patients. The therapeutic dose should be administered for 10 days.

Prevention of Recurrent Attacks of Rheumatic Fever:
Penicillin or sulphonamides are considered to be the drugs of choice in the prevention of recurrent attacks of rheumatic fever. In patients who are allergic to penicillin and sulphonamides, oral erythromycin is recommended in the long term prophylaxis of streptococcal pharyngitis (for the prevention of recurrent attacks of rheumatic fever).

Prevention of Bacterial Endocarditis:
Although no controlled clinical efficacy trials have been conducted, oral erythromycin has been recommended for prevention of bacterial endocarditis in penicillin-allergic patients with prosthetic cardiac valves, most congenital cardiac malformations, surgically constructed systemic pulmonary shunts, rheumatic or other acquired valvular dysfunction, idiopathic hypertrophic subaortic stenosis (IHSS), previous history of bacterial endocarditis or mitral valve prolapse with insufficiency when they undergo dental procedures or surgical procedures of the upper respiratory tract.

Alpha-haemolytic streptococci (viridans group):
Although no controlled clinical efficacy trials have been conducted, oral erythromycin has been suggested for use in a regimen for prophylaxis against bacterial endocarditis in patients hypersensitive to penicillin who have congenital heart disease, or rheumatic or other acquired valvular heart disease when they undergo dental procedures or surgical procedures of the upper respiratory tract. Erythromycin is not suitable prior to genitourinary or gastrointestinal tract surgery.

Staphylococcus aureus:
Acute infections of skin and soft tissue of mild to moderate severity. Resistant organisms may emerge during treatment.

Streptococcus pneumoniae (Diplococcus pneumoniae):
Upper respiratory tract infections (e.g. otitis media, pharyngitis) and lower respiratory tract infections (e.g. pneumonia) of mild to moderate degree.

Mycoplasma pneumoniae (Eaton agent, PPLO):
For respiratory infections due to this organism.

Haemophilus influenzae:
For upper respiratory tract infections of mild to moderate severity. Not all strains of this organism are susceptible to erythromycin at concentrations achieved with usual therapeutic doses; resistant strains may require concomitant therapy with sulphonamides.

Ureaplasma urealyticum:
For the treatment of urethritis caused by these organisms in adult males.

Neisseria gonorrhoeae:
ERA-IV (erythromycin lactobionate for injection) in conjunction with erythromycin orally, as an alternative drug in treatment of acute pelvic inflammatory disease caused by N. gonorrhoeae in female patients with a history of sensitivity to pencillin. Before treatment of gonorrhoea, patients who are suspected of also having syphilis should have a microscopic examination for T. pallidum (by immunofluorescence or darkfield) before receiving erythromycin, and monthly serologic tests for a minimum of 4 months thereafter.

Chlamydia trachomatis:
Erythromycin is indicated for treatment of the following infections caused by Chlamydia trachomatis; conjunctivitis of the newborn, pneumonia of infancy and urogenital infections during pregnancy (see Warnings and Precautions). When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical or rectal infections in adults due to Chlamydia trachomatis.

Treponema pallidum:
Erythromycin is an alternate choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid examinations should be done before treatment and as part of follow-up therapy. Erythromycin should not be used for the treatment of syphilis in pregnancy because it cannot be relied upon to cure an infected foetus.

Corynebacterium diphtheriae:
As an adjunct to antitoxin, to prevent establishment of carriers, and to eradicate the organism in carriers.

Corynebacterium minutissimum:
For the treatment of erythrasma.

Entamoeba histolytica:
In treatment of intestinal amoebiasis only. Extra-enteric amoebiasis requires treatment with other agents.

Listeria monocytogenes:
Infections due to this organism.

Bordetella pertussis:
Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals, rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals.

Legionnaire's Disease:
Clinical evidence suggests that erythromycin is the preferred antibiotic for treating Legionnaire's Disease

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